Absorption and Drug Development: Solubility, Permeability, by Alex Avdeef PDF

By Alex Avdeef

ISBN-10: 1118057457

ISBN-13: 9781118057452

Explains the right way to practice and learn the result of the most recent physicochemical methods

With this booklet as their consultant, readers have entry to all of the present info had to completely examine and correctly verify a compound's pharmaceutical houses and their results on drug absorption. The booklet emphasizes oral absorption, explaining the entire physicochemical tools used at the present time to investigate drug applicants. additionally, the writer offers professional counsel to assist readers examine the result of their reports so one can choose the main promising drug candidates.

This Second Edition has been completely up-to-date and revised, incorporating all of the newest learn findings, equipment, and assets, including:

  • Descriptions and functions of recent PAMPA types, drawing on greater than thirty papers released through the author's study group

  • Two new chapters studying permeability and Caco-2/MDCK and permeability and the blood-brain barrier

  • Expanded info and strategies to aid pKa determination

  • New examples explaining the therapy of virtually insoluble try compounds

  • Additional case reports demonstrating using the newest physicochemical techniques

  • New, revised, and elevated database tables in the course of the book

Well over two hundred drawings support readers larger comprehend tricky suggestions and supply a visible consultant to complicated tactics. additionally, over 800 references function a gateway to the first literature within the box, facilitating extra examine into all of the issues coated within the book.

This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable parts of analysis. it's also prompt as a supplemental textual content for graduate classes in pharmaceutics.

Show description

Read Online or Download Absorption and Drug Development: Solubility, Permeability, and Charge State PDF

Similar industrial & technical chemistry books

Unit Operations of Particulate Solids: Theory and Practice - download pdf or read online

Compatible for practising engineers and engineers in education, Unit Operations of Particulate Solids: idea and perform offers the unit operations in chemical engineering that contain the dealing with and processing of particulate solids. the 1st a part of the ebook analyzes fundamental and secondary homes of debris and particulate platforms, targeting their characterization and the consequences on choice and layout of silos and conveyors.

Read e-book online Tuning Semiconducting and Metallic Quantum Dots: PDF

Nanotechnology is without doubt one of the starting to be components of this century, additionally starting new horizons for tuning optical houses. This e-book introduces easy tuning schemes, together with these on a unmarried quantum item point, with an emphasis on floor and interface manipulation of semiconducting and steel quantum dots.

Download e-book for kindle: Alternative Kraftstoffe für die dieselmotorische Verbrennung by Linda Witzke

Linda Witzke befasst sich mit der Frage, inwiefern kohlenhydratbasierte Biomasse als Rohstoff zur Herstellung alternativer Dieselkraftstoffe genutzt werden kann. Am Beispiel ausgewählter Kraftstoffe werden mögliche bio- und chemisch-katalytische Herstellverfahren aus Zucker konzipiert und mithilfe einer vergleichenden Bewertungsmethodik hinsichtlich der verfahrenstechnischen Machbarkeit und Prozessbilanzen sowie der Kraftstoffherstellungskosten untersucht.

New PDF release: Solid-State Properties of Pharmaceutical Materials

Provides a close dialogue of vital solid-state homes, tools, and purposes of solid-state research Illustrates some of the levels or types that solids can imagine and discussesvarious concerns with regards to the relative balance of stable types and traits to suffer transformation Covers key equipment of sturdy kingdom research together with X-ray powder diffraction, thermal research, microscopy, spectroscopy, and strong kingdom NMR experiences severe actual attributes of pharmaceutical fabrics, as a rule concerning drug components, together with particle size/surface sector, hygroscopicity, mechanical homes, solubility, and actual and chemical balance Showcases the appliance of reliable country fabric technological know-how in rational collection of drug stable kinds, research of varied stable kinds inside of drug substance and the drug product, and pharmaceutical product improvement Introduces applicable production and regulate strategies utilizing caliber by way of layout, and different suggestions that result in secure and powerful items with no less than assets and time

Extra resources for Absorption and Drug Development: Solubility, Permeability, and Charge State

Example text

Download PDF sample

Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef


by Ronald
4.2

Rated 4.18 of 5 – based on 38 votes