Absorption and Drug Development: Solubility, Permeability, by Alex Avdeef PDF

By Alex Avdeef

ISBN-10: 1118057457

ISBN-13: 9781118057452

Explains the right way to practice and learn the result of the most recent physicochemical methods

With this booklet as their consultant, readers have entry to all of the present info had to completely examine and correctly verify a compound's pharmaceutical houses and their results on drug absorption. The booklet emphasizes oral absorption, explaining the entire physicochemical tools used at the present time to investigate drug applicants. additionally, the writer offers professional counsel to assist readers examine the result of their reports so one can choose the main promising drug candidates.

This Second Edition has been completely up-to-date and revised, incorporating all of the newest learn findings, equipment, and assets, including:

  • Descriptions and functions of recent PAMPA types, drawing on greater than thirty papers released through the author's study group

  • Two new chapters studying permeability and Caco-2/MDCK and permeability and the blood-brain barrier

  • Expanded info and strategies to aid pKa determination

  • New examples explaining the therapy of virtually insoluble try compounds

  • Additional case reports demonstrating using the newest physicochemical techniques

  • New, revised, and elevated database tables in the course of the book

Well over two hundred drawings support readers larger comprehend tricky suggestions and supply a visible consultant to complicated tactics. additionally, over 800 references function a gateway to the first literature within the box, facilitating extra examine into all of the issues coated within the book.

This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable parts of analysis. it's also prompt as a supplemental textual content for graduate classes in pharmaceutics.

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Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef

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